Asthma is the most common chronic lung disease of childhood, affecting approximately 6 million children in the United States.1 It is well recognized that asthma development depends on both genetic and environmental factors, originates early in life, and leads to chronic respiratory symptoms and airflow limitation. Although progress has been made in the care of children with asthma, including the reduction of adverse health outcomes and improvement of asthma control,1 we lack strategies to prevent asthma development or cure it. This knowledge gap stems from an incomplete understanding of the mechanisms leading to asthma development.
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