DEVELOPMENTAL PATTERN OF PLASMA SEX STEROID BINDING PROTEIN |[lpar]|SBP|[rpar]| IN THE ANDROGEN INSENSITIVITY SYNDROME |[lpar]|AIS|[rpar]|: PUBERTAL CHANGES INDEPENDENT OF SEX STEROIDS |[quest]|

摘要

SBP was measured by a solid phase method in 80 plasma samples from 24 AIS subjects 1 mo-17 yr old. Results (μg/l) were compared to those found in 375 normal males matched for age. Weight was normal for height in all. In AIS infants, SBP was in the normal range. In AIS children, mean (±SD) SBP levels were 18.7±3.5 at 1-9 yr, and 14.4±5.3 at 11-13 yr, similar to that in normals (19.8±7.5 and 15.7±8.1). Values at 15-17 yr (13.1±5.6) were significantly (p<0.02) lower than at 1-9 yr, but higher than in normals matched for age (9.2±4.2) or testosterone (T) levels. A significant (p=0.03) correlation between SBP and age was found at 8-17 yr, but not before. These results are in general accordance with that of Cunningham et al. (JCEM, 1984, 58, 915) who reported at 38-46% fall in SBP in 2 AIS patients 8-16 yr old. The mean % fall is less in our larger series. In addition, we observed large indidual variations, both in absolute values and in the degree of changes. This was even more evident in the longitudinal study made in 6 AIS patients: a significant correlation with age was found in only 3. In conclusion: 1) In AIS infants and children SBP is in the normal range. 2) After puberty, SBP is significantly higher in AIS than in normals. 3) At the normal age of puberty, mean SBP plasma levels fall of 30% in AIS patients versus 55% in controls; this difference may account for the influence of T in normal subjects. Assuming that in AIS, T is inactive on hepatic cell as in other target cells, then about half of the pubertal fall in SBP in not T-mediated.