Parkin‐mediated selective mitochondrial autophagy, mitophagy: Parkin purges damaged organelles from the vital mitochondrial network

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Parkin‐mediated selective mitochondrial autophagy, mitophagy: Parkin purges damaged organelles from the vital mitochondrial network

机译：Parkin介导的选择性线粒体自噬，线粒体：Parkin从重要的线粒体网络清除受损的细胞器

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Cellularhomeostasisislinkedtightlytomitochondrialfunctions.Somedamagetomitochondrialproteinsandnucleicacidscanleadtothedepolarizationoftheinnermitochondrialmembrane,therebysensitizingimpairedmitochondriaforselectiveeliminationbyautophagy.Mitochondrialdysfunctionisoneofthekeyaspectsofthepathobiologyofneurodegenerativedisease.Parkin,anE3ligaselocatedinthecytosolandoriginallydiscoveredasmutatedinmonogenicformsofParkinson'sdisease(PD),wasfoundrecentlytotranslocatespecificallytouncoupledmitochondriaandtoinducetheirautophagy...

机译：Cellularhomeostasisislinkedtightlytomitochondrialfunctions.Somedamagetomitochondrialproteinsandnucleicacidscanleadtothedepolarizationoftheinnermitochondrialmembrane，therebysensitizingimpairedmitochondriaforselectiveeliminationbyautophagy.Mitochondrialdysfunctionisoneofthekeyaspectsofthepathobiologyofneurodegenerativedisease.Parkin，anE3ligaselocatedinthecytosolandoriginallydiscoveredasmutatedinmonogenicformsofParkinson'sdisease（PD），wasfoundrecentlytotranslocatespecificallytouncoupledmitochondriaandtoinducetheirautophagy ...

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《FEBS Letters》 |2010年第7期|共7页
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1. Parkin-mediated selective mitochondrial autophagy, mitophagy: Parkin purges damaged organelles from the vital mitochondrial network. [J] . Tanaka A FEBS letters. . 2010,第7期

机译：Parkin介导的选择性线粒体自噬，线粒体：Parkin从重要的线粒体网络清除受损的细胞器。
2. Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming [J] . Wen-Xing Ding, Hong-Min Ni, Min Li, The Journal of biological chemistry . 2010,第36期

机译：NIX对于两种不同的斑块相，反应性氧物种介导的自噬诱导和Parkin-ubiquitin-P62介导的线粒体引发至关重要
3. Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway [J] . Wu Xinwei, Li Xuemei, Liu Yi, Brain research . 2018,第期

机译：通过通过调节Pink1 / Parkin信号通路介导的乳化物来保护线粒体功能，氢气对大鼠海马中OGD / R受损神经元的神经保护作用进行了神经保护作用
4. Mitochondrial Fragmentation Mediates MPP~+ Toxicity in Neurons: Implications for Parkinson's Disease [C] . Xinglong Wang, Mark A. Smith, George Perry, International Metallographic Society Annual meeting;Microscopy Society of America Annual Meeting;Microanalysis Society Annual meeting . 2011

机译：线粒体片段介导神经元的MPP〜+毒性：对帕金森氏病的影响
5. Regulation of mitochondrial fates and cellular metabolism via Parkin-mediated mitophagy and interaction between apoptosis and autophagy pathways in cancer [D] . Wang, Sih-han 2012

机译：通过帕金介导的线粒体吞噬调节线粒体命运和细胞代谢以及癌症中细胞凋亡与自噬途径之间的相互作用
6. Parkin-mediated selective mitochondrial autophagy mitophagy: Parkin purges damaged organelles from the vital mitochondrial network [O] . Atsushi Tanaka -1

机译：Parkin介导的选择性线粒体自噬mitophy：Parkin从重要的线粒体网络中清洗受损的细胞器
7. Parkin-mediated selective mitochondrial autophagy, mitophagy: Parkin purges damaged organelles from the vital mitochondrial network [O] . Tanaka Atsushi 2010

机译：Parkin介导的选择性线粒体自噬，线粒体：Parkin从重要的线粒体网络清除受损的细胞器

Parkin‐mediated selective mitochondrial autophagy, mitophagy: Parkin purges damaged organelles from the vital mitochondrial network

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