Tumour‐suppressive microRNA‐29s directly regulate LOXL2 expression and inhibit cancer cell migration and invasion in renal cell carcinoma

摘要

Here,wefoundthatmembersofthemicroRNA‐29family(miR‐29a/b/c;“miR‐29s”)weresignificantlyreducedinclearcellrenalcellcarcinoma(ccRCC)tissues,suggestingthattheyfunctionedastumoursuppressors.RestorationofallmaturemembersofthemiR‐29familyinhibitedcancercellproliferation,migrationandinvasion.LOXL2wasadirecttargetgeneofmiR‐29s,asshownbygenome‐widegeneexpressionanalysisandluciferasereporterassay.OverexpressedLOXL2wasconfirmedinccRCCclinicalspecimens,andsilencingofLOXL2inhibitedcancercellmigrationandinvasioninccRCCcelllines.OurdatademonstratedthatthemiR‐29s‐LOXL2axiscontributedtocancercellmigrationandinvasioninccRCC...