STAT3, but not ERKs, mediates the IL-6|[ndash]|induced proliferation of renal cancer cells, ACHN and 769P

摘要

STAT3, but not ERKs, mediates the IL-6–induced proliferation of renal cancer cells, ACHN and 769P.BackgroundAlthough interleukin-6 (IL-6) has been suggested to function as an autocrine growth factor in renal cell carcinoma (RCC), the underlying mechanism responsible for the IL-6–induced proliferation of RCC has not been defined. The aim of this study was to characterize the signaling cascades mediating IL-6–induced proliferation and to investigate the use of effective novel interventions to block the IL-6–induced autocrine growth of renal cancer cells.