TGF-|[bgr]|1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2)

摘要

TGF-1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2).BackgroundThe prognosis of primary renal disease is often dependent on the degree of tubulointerstitial scarring. Scarring is caused by proliferation and excessive matrix production of renal fibroblasts and possibly other cellular elements. Transforming growth factor- (TGF-) is the most important cytokine for the induction of matrix synthesis in the kidney. However, its effects on renal fibroblast proliferation have not been determined. We have recently demonstrated that the expression of basic fibroblast growth factor (FGF-2) is robustly up-regulated in human kidneys with tubulointerstitial fibrosis and that FGF-2 is a potent inducer of fibroblast proliferation. The present study examined the interaction between TGF-1 and FGF-2 in human renal fibroblasts.