A Novel Distribution of Visual Field Test Points to Improve the Correlation between Structurea??Function Measurements

摘要

Purpose.: To create a new visual field (VF) test grid centered at the optic disc (disc-centered field [DCF]) and to infer the combination of VF test points (structurea??function field [SFF]), taken from the DCF and the conventional fovea-centered 24-2 grid (24-2) of standard automated perimetry, which yields the strongest sectorial correlation between structurea??function measurements of retinal nerve fiber layer (RNFL) thickness and VF sensitivity. Methods.: In 50 eyes with ocular hypertension or open angle glaucoma, the DCF and 24-2 VF were measured with a Humphrey Field Analyzer II (Full Threshold strategy) and RNFL thickness was measured with Stratus optical coherence tomography. Test points from the DCF and 24-2 VF were combined and divided into 12 sectors according to the spatial distribution of the RNFL. A novel VF for structurea??function studies was established using the following criteria: each sector must contain at least one or two test points (depending on the sector's location), and the combination of test points which yields the strongest structurea??function correlation is selected. Results.: The SFF consisted of 40 test points. The structurea??function correlation for the SFF was compared with the standard 24-2 VF; a multiple-comparison test for dependent groups was carried out using a percentile bootstrap method, which indicated that the sector correlation coefficients in the SFF were significantly higher than those in the 24-2 VF. Conclusions.: The SFF, with fewer test locations, has a stronger structurea??function correlation than the 24-2 VF. This improved correlation may help clinicians to better interpret functional measurements in relation to structural measurements.