Wet SiO2 As a Suitable Media for Fast and Efficient Reduction of Carbonyl Compounds with NaBH3CN under Solvent-Free and Acid-Free Conditions

摘要

Reduction of carbonyl compounds such as aldehydes, ketones, メ,モ-unsaturated enals and enones, メ-diketones and acyloins was carried out readily with NaBH₃CN in the presence of wet SiO₂ as a neutral media. The reactions were performed at solvent-free conditions in oil bath (70 - 80 ^oC) or under microwave irradiation (240 W) to give the product alcohols in high to excellent yields. Regioselective 1,2-reduction of conjugated carbonyl compounds took place in a perfect selectivity without any side product formation.