A New Chiral Synthetic Route to (+)-Isocarbacyclin

摘要

A synthetic route to (+)-isocarbacyclin starting from (-)-tricyclo[3.3.0.02,8]octan-3-one 6 is described. The key intermediate 4 has been synthesized from 6 by a sequential introduction of methoxycarbonyl group at C-12 and the oxygen functionality at C-9メ (PG numbering) for the construction of メ-and -side chain, and then converted to isocarbacyclin methyl ester 2.