ASSOCIATION OF SERUM SOLUBLE LEPTIN RECEPTOR AND LEPTIN LEVELS WITH BREAST CANCER

摘要

Background: Leptin plays a key role in the regulation of energy expenditure and is known to circulate in both free and bound forms. Soluble leptin receptor ( sOB -R) is a unique circulating form of leptin receptor that can bind to leptin . Leptin and leptin receptor have been implicated in processes leading to breast cancer initiation and progression. Our study was aimed to investigate the relationship between serum levels of sOB -R and leptin with breast cancer.Materials and Methods: Serum leptin and sOB -R levels were measured by enzyme-linked immunosorbent assay in 100 women with breast cancer cases compared with 100 age and body mass index (BMI)-matched controls without cancer. Lipid profiles were measured by enzymatic method.Results: The median serum levels of sOB -R in controls were significantly higher than that in breast cancer cases (odds ratio [OR], 1.98; 95% confidence interval [CI] =0.77-188.2) versus (OR, 0.140; 95% CI=0.09-98.1). Conversely, the median serum level of leptin in breast cancer cases was significantly higher than that in controls (OR, 67.90; 95% CI=2.77-129.9) vs. (OR, 28.30; 95% CI=0.60-113.1). Breast cancer was significantly associated with higher serum level of leptin (OR=1.027, 95% CI=1.017-1.038). Conversely, breast cancer was correlated with lower serum level of sOB -R (OR=0.983, 95% CI=0.969-0.997). Moreover, free leptin index (FLI) ( leptin / sOB -R ratio) was associated with breast cancer (OR=1.028, 95% CI=1.015-1.042). The serum sOB -R level was negatively associated with leptin , BMI, and high density lipoprotein (r=-0.238, -0.186, and -0.168, respectively).Conclusion: Our results suggested that FLI and serum leptin level rather than serum level of sOB -R was associated with the breast cancer.