THE EFFECTS OF DEXMEDETOMIDINE ON HEMODYNAMIC RESPONSES TO TRACHEAL INTUBATION IN HYPERTENSIVE PATIENTS: A COMPARISON WITH ESMOLOL AND SUFENTANYL

摘要

BACKGROUND: Hypertension and tachycardia caused by tracheal intubation can be detrimental in hypertensive patients.This study was conducted in order to compare the effects of dexmedetomidine on hemodynamic response to tracheal intubation in hypertensive patients with esmolol and sufentanyl.METHODS: Sixty hypertensive patients scheduled for noncardiac surgery under general anesthesia were randomly assigned to receive one of the three drugs before induction of anesthesia. Groups I, II, and III respectively received esmolol (100 mg) dexmedetomidine (1 m g/kg) and sufentanyl (0.25 m g/kg). Heart Rate (HR), systolic (SAP) and diastolic (DAP) arterial pressures were recorded before drug administration (baseline; T1), after drug administration (T2), after induction of anesthesia (T3), immediately after intubation (T4) and 3, 5 and 10 minutes after intubation (T5, T6, and T7, respectively). The mean percentage variations from T1 to T4 were calculated for all variables (HR, SAP and DAP). Thiopental dose, onset time of vecuronium and intubation time were also assessed.RESULTS: No differences were observed between the three groups regarding demographic data (p>0.05). Median thiopental dose was significantly lower in Group II (325 mg; range: 250-500) compared to Group I (425 mg; range: 325-500; pCONCLUSIONS: In hypertensive patients, administration of dexmedetomidine before anesthesia induction blunts the hemodynamic response to tracheal intubation and reduces the thiopental dose.