Endoscopic Findings of Upper Gastrointestinal Lesions in Patients with Pancreatic Cancer

摘要

Context Pancreatic cancer is oftencomplicated with upper gastrointestinal lesions. However, there have been fewendoscopic studies in pancreatic cancer patients. We retrospectivelyinvestigated the upper gastrointestinal lesions in patients with pancreaticcancer who underwent upper gastrointestinal endoscopy. Methods Uppergastrointestinal endoscopy was performed in 75 patients with pancreatic cancerbetween 2003 and 2010. We examined upper gastrointestinal lesions, such asgastroduodenal invasion, ulcers, esophagogastric varices, radiation-inducedgastroduodenal mucosal lesions, and portal hypertensive gastropathy. ResultsAmong the 53 patients with pancreatic cancer who underwent uppergastrointestinal endoscopy at diagnosis, 23 gastrointestinal lesions wereobserved in 20 patients (38%) as follows: gastroduodenal invasion (n=11),esophagogastric varices (n=7), gastroduodenal ulcers (n=3), portal hypertensivegastropathy (n=1) and duodenal metastasis (n=1). Among the 75 patients withpancreatic cancer, 56 gastrointestinal lesions were identified in 46 patients (61%)during the clinical course as follows: gastroduodenal invasion (n=20),esophagogastric varices (n=14), radiation-induced gastroduodenal mucosallesions (n=9), gastroduodenal ulcers (except radiation-induced ulcers) (n=8),portal hypertensive gastropathy (n=3), duodenal metastasis (n=1), andgastrointestinal bleeding from unknown primary site (n=1). Twenty-nine (52%) ofthe 56 gastrointestinal lesions showed symptoms related to the lesions. Fifteen(27%) lesions were accompanied by upper gastrointestinal bleeding. Fourteen(25%) lesions developed according to the progression of pancreatic cancer. ConclusionWe should pay attention to upper gastrointestinal lesions in patients withpancreatic cancer.