Edema and Congestive Heart Failure from Thiazolidone Insulin Sensitizersa€”Excess Sodium Reabsoption in the Collecting Duct Collecting Duct-Specific Deletion of Peroxisome Proliferator-Activated Receptor ?3 Blocks Thiazolidinedione-Induced Fluid Retention. Proc Nat Acad Sci U S A 102: 9406a€“9411, 2005

摘要

Thiazolidinediones Expand Body Fluid Volume through PPAR?3 Stimulation of ENaC-Mediated Renal Salt Absorption