Early biomarkers in neonatal necrotizing enterocolitis:

摘要

Background Necrotizing enterocolitis (NEC) is a frequent serious disease of the digestive system in neonates. It is considered as an important cause of serious neonatal complication and death. Therefore, its early suspi-cion and proper management are important. Aim Early and sensitive detection of neonatal NEC through determination of levels of fecal calprotectin (FCP), serum levels of procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), epithelial neutrophil activating peptide-78 (ENA-78), and interleukin 18 (IL-18). Method This prospective case control study was conducted in Tanta University Hospital from June 2016 to March 2018. The study included 20 healthy neonates (control group) and 20 NEC newborn patients. They were all subjected to the measurement of levels of FCP and serum levels of hs-CRP, PCT, ENA- 78, IL-18, Malondialdehyde (MDA), and total antioxidant capacity (TAC). Receiver operating charac- teristic (ROC) curve analysis was conducted for FCP, ENA-78, PCT, hs-CRP, and IL-18. Results The study found a detectable?increase in FCP level and serum levels of hs-CRP, PCT, ENA-78, IL-18, and MDA in NEC group in comparison to their levels in the control group. Also, it found a detectable decline in the levels of TAC in comparison to its level in the control group. Conclusion FCP, ENA-78, and PCT can be considered as early markers for diagnosis of NEC.