In vitro and in vivo evaluation of macro-pore bioglass bone blocks and the application in load-bearing defective bone

摘要

Seeking for a kind of suitable bone biomaterials to repair the heavy defective bone of load-bearing region is an essential mission and effort direction of materials experts and Orthopaedics Surgeons. Current biomaterials used in load-bearing region are limited because of poor bioactivity. Therefore the generation of bioactive bone substitute with improved mechanical features is a possible way to dissolve these clinical problems. We develop a new bioactive bone substitute, Macro- Pore Bone Block (MPBB), which presents good biomechanical strength and persisting bioactivity. We implanted it into the femoral condyles of rabbits and also, cultured osteoblasts on the surface of the material in vitro. The MPBB presents better mechanical strength and shows a good bioactivity and appropriate degradation rate in the in vivo study. MPBB is also proved to promote osteoblast adhesion, proliferation and differentiation in vitro. Furthermore, even a clinical case application of the customized MPBB in pelvic Pemberton osteotomy shows a sufficient compressive strength and wonderful biological activity which demonstrates the good clinical effect. As such, this novel Bioglass-based graft material might be a novel alternative in the reconstructions of hard tissue, especially for use in application that require high load bearing implant materials.