Multicenter Study of Contraceptive Vaginal Ring (NuvaRing?) in Normal Daily Practice in Indian Women

摘要

Objective This was the first Indian multicenter study at six specialty hospitals, to assess the real-life usage of the vaginal ring in daily clinical practice. Methods This open-label, prospective, single-arm, nonrandomized, interventional study enrolled 252 women aged >18?years, seeking contraception with no contraindications to the use of combined hormonal contraceptive. Women were provided the ring with a monthly follow-up schedule for three cycles. Cycle control, acceptability, tolerability, and safety assessments were recorded at each visit. Results Regular menstrual bleeding was reported by 76.2?% (192/252) at baseline. In study completers, regular bleeding was seen in 94.1?% (192/204), 97.5?% (199/204), and 98?% (200/204) in the 1st, the 2nd, and the 3rd cycles, respectively. Most (94.2?% [195/207]) women were very satisfied or satisfied with the ring, and 93.2?% (193/207) would recommend it to others. No pregnancies or serious adverse events were reported. Conclusion The study demonstrated that NuvaRing? is a highly effective contraceptive method with an excellent cycle control. It is well tolerated and accepted by Indian women.