GC–MS analysis for compound identification in leaf extract of Lumnitzera racemosa and evaluation of its in vitro anticancer effect against MCF7 and HeLa cell lines

摘要

The aim of present study is to analyze and separate bioactive constitutes of methanol leaf extract fromLumnitzera racemosaby Gas chromatography–Mass spectroscopy (GC–MS) and further to test forin vitroanticancer activity on MCF 7 and HeLa cancer cells using MTT assay. GC–MS analysis ofL.racemosaleaf extract showed the presence of different bioactive compounds mainly: furfurals and fatty acids. The bioactive compounds present inL. racemosarevealed significant cytotoxic activity against MCF 7 with IC50value, 46.098?μg/mL and HeLa cells with IC50value of 59.497?μg/mL. The leaf extracts ofL. racemosahas high anticancer activity on MCF 7 cells in comparison with HeLa cell lines.