SAP3 Gene Expression as Diagnostic Marker of Oral Candidiasis In HIV/AIDS Patients

摘要

HIV/AIDS cases growth progressively. Oral Candidiasis frequently found in the tract ofpathogenesis HIV infection, these condition due to immunocompromised condition amongHIV/AIDS patient and one higher complications insidence in oral. Until now, type of cell andreceptor of oral mucosa as particularly target of HIV has not been well understood. SecretoryAspartyl Proteinase (SAP) is hydrolytic enzyme secreted by C. albicans which might destructprotein in the site of infection. This enzyme coding by SAP gene and contribute to C. albicansvirulency. The aim of this research is to found the expression of SAP3 as the predictor of HIVseverity. 30 HIV patients divided into two groups, one group with ARV therapeutic indication (15patients) and the other group without ARV therapeutic indication. The cotton swab has been donein buccal mucous and dorsum of tongue. The detection would be done by PCR.The result is showed in non-ARV, revealed the presence of SAP3 gene in all samples, butSAP3 gene was not found in all HIV/AIDS samples with ARV. SAP3 could be used as indicator ofHIV/AIDS severity, since it was an oral infecton marker related with the degree of hostimmunodeficiency and C. albicans virulence level.