Effect of early enteral nutrition intervention on nerve function, systemic oxidative stress and inflammatory response in patients with hypertensive cerebral hemorrhage

摘要

Objective: To study the effect of early enteral nutrition intervention on nerve function, systemicoxidative stress and inflammatory response in patients with hypertensive cerebral hemorrhage.Methods: A total of 98 patients with hypertensive cerebral hemorrhage who receivedhospitalization in the hospital between April 2015 and February 2017 were collected anddivided into control group and observation group by random number table method, 49 casesin each group. Control group received routine enteral nutrition intervention and observationgroup received early enteral nutrition intervention. The differences in serum levels of nervefunction-related indexes, oxidative stress indexes and inflammatory mediators were comparedbetween the two groups of patients before and after intervention. Results: Before intervention,the differences in serum levels of nerve function-related indexes, oxidative stress indexes andinflammatory mediators were not statistically significant between the two groups of patients.After 1 week of intervention, serum S100B, NSE, GFAP, MBP, LPO, MDA, PCT, IL-1β, IL-6and TNF-α levels of both groups of patients were lower than those before intervention whileGSH-PX levels were higher than those before intervention, and serum S100B, NSE, GFAP,MBP, LPO, MDA, PCT, IL-1β, IL-6 and TNF-α levels of observation group were lower thanthose of control group while GSH-PX level was higher than that of control group. Conclusion:Early enteral nutrition intervention can effectively optimize the nerve function and suppressthe systemic oxidative stress and inflammatory response in patients with hypertensive cerebralhemorrhage.