Effect of lung lavage via fiber bronchoscope combined with non-invasive positive pressure ventilation on the blood gas results and systemic state of patients with COPD complicated by severe pneumonia

摘要

Objective: To discuss the effect of lung lavage via fiber bronchoscope combined with noninvasivepositive pressure ventilation on the blood gas results and systemic state of patientswith COPD complicated by severe pneumonia. Methods: A total of 68 patients with COPDcomplicated by severe pneumonia who were treated in the hospital between November 2015and April 2017 were collected, retrospectively analyzed and then divided into the group A(n=35) who received noninvasive positive pressure ventilation and the group B (n=33) whoreceived lung lavage via fiber bronchoscope combined with non-invasive positive pressureventilation. The differences in arterial blood gas and serum index levels were comparedbetween the two groups before and after treatment. Results: Before treatment, there was nostatistically significant difference in arterial blood gas index levels as well as serum contents ofinflammatory mediators, stress hormones and myocardial enzyme spectrum indexes betweenthe two groups. After treatment, arterial blood gas indexes PH and PaO2 levels of group Bwere higher than those of group A; serum inflammatory mediators HMGB1, PCT and hs-CRPcontents were lower than those of group A; serum stress hormones Cor, AngⅠ and AngⅡcontents were lower than those of group A; serum myocardial enzyme spectrum indexesα-HBDH and cTn-Ⅰ contents were lower than those of group A. Conclusion: Lung lavagevia fiber bronchoscope combined with non-invasive positive pressure ventilation can effectivelyoptimize the arterial blood gas levels, reduce systemic inflammatory stress state and protect themyocardial function of patients with COPD complicated by severe pneumonia.