Changes in plaque stability, cell apoptosis and coagulation indexes after patients with unstable angina pectoris accept adjuvant salvianolate therapy

摘要

Objective: To investigate the effect of adjuvant salvianolate therapy on plaque stability, cellapoptosis and coagulation indexes in patients with unstable angina pectoris. Methods: 92patients with unstable angina pectoris treated in our hospital between May 2011 and August2015 were collected, and after the treatment process and auxiliary examination results wereretrospectively analyzed, they were divided into the control group (n=45) who acceptedconventional treatment and the observation group (n=47) who accepted adjuvant salvianolatetreatment. Before and after treatment, diasonograph was used to evaluate the plaque stabilityparameters of two groups of patients; ELISA was used to detect apoptosis-related moleculelevels; immunoturbidimetry was used to detect blood coagulation indexes. Results: Beforetreatment, differences in plaque stability parameters, cell apoptosis molecules and coagulationindexes were not statistically significant between two groups of patients (P0.05). Aftertreatment, the plaque stability parameters plaque thickness, enhanced intensity, rise time andtime to peak of observation group were significantly lower than those of control group (P0.05);serum sFas, sFasL, fibrinogen (Fib), platelet (PLT), and D-Dimer (D-D) levels of observationgroup were significantly lower than those of control group while Bcl-2, prothrombin time (PT)and activated partial thromboplastin time (APTT) levels were significantly higher than those ofcontrol group (P0.05). Conclusions: Adjuvant salvianolate treatment can increase the plaquestability, also inhibit myocardial cell apoptosis and improve the coagulation function in patientswith unstable angina pectoris.