Observation on the effect of adefovir dipivoxil in combined with lamivudine in the treatment of hepatitis B cirrhosis

摘要

Objective: To explore the effect of adefovir dipivoxil in combined with lamivudine on theliver function in patients with hepatitis B cirrhosis and the antiviral efficacy. Methods: A totalof 156 patients with hepatitis B cirrhosis who were admitted in our hospital were includedin the study and randomized into the treatment group and the control group with 78 cases ineach group. The patients in the treatment group were given adefovir dipivoxil in combinedwith lamivudine, while the patients in the control group were given entecavir. After 12-monthtreatment, the efficacy was evaluated. The liver function, serum virology indicators, and AFPbefore and after treatment in the two groups were compared. The adverse reactions during thetreatment process were recorded. Results: The serum GTP, ALT, AST, and TBIL levels aftertreatment in the two groups were significantly reduced when compared with before treatment(P0.05). ALT normalization rate and HBeAg negative conversion rateafter treatment in the treatment group were significantly higher than those in the control group(P0.05). No obvious drug adversereactions and liver function damage occurred during the treatment process in the two groups.Conclusions: Adefovir dipivoxil in combined with lamivudine can significantly improve theliver function and serum virology indicators in patients with hepatitis B cirrhosis, with antiviralefficacy significantly superior to that by entecavir.