Relationship of JAK2V617F gene mutation with cell proliferation and coagulation function in myeloproliferative neoplasms

摘要

Objective: To study the relationship of JAK2V617F gene mutation with cell proliferationand coagulation function in myeloproliferative neoplasms. Methods: Patients who werediagnosed with BCR-ABL-negative myeloproliferative neoplasms in Anyang District Hospitalbetween June 2014 and August 2016 were selected, JAK2V617F gene mutation was detected,and according to the test results, the patients were divided into mutation-positive group andmutation-negative group. The expression of JAK2/STATs signaling pathway molecules andcell proliferation genes in bone marrow fluid as well as the coagulation function indexes inperipheral blood were detected. Results: p-JAK2, p-STAT3, p-STAT5, Survivin, C-myc,CyclinD1 and ASXL1 protein expression in myeloproliferative neoplasms of mutation-positivegroup were significantly higher than those of mutation-negative group, and peripheral blood PTand APTT levels were significantly lower than those of mutation-negative group while TT andFIB levels were not significantly different from those of mutation-negative group. Conclusion:JAK2V617F gene mutation in myeloproliferative neoplasms can promote the cell proliferationand cause the hypercoagulable state.