Effects of Ginkgo biloba extract adjuvant therapy on inflammatory reaction, adhesion molecules and antioxidant function in patients with cerebral infarction complicated with hyperhomocysteinemia

摘要

Objective: To investigate the effects of Ginkgo biloba extract adjuvant therapy oninflammatory reaction, adhesion molecules and antioxidant function in patients with cerebralinfarction complicated with hyperhomocysteinemia. Methods: A total of 114 patients withcerebral infarction complicated with hyperhomocysteinemia who were conformed to theresearch selection criteria were selected as the research objects, according to the random datatable method they were evenly divided into the control group (n=57) and the observationgroup (n=57), patients in the two groups were given conventional supportive treatment, onthis basis, the control group patients were given folic acid tablets and vitamin B12 treatment,the observation group was treated with Ginkgo biloba extract dripping pills on the basis of thetreatment of the control group. The levels of inflammatory factors, adhesion molecules andantioxidant and antioxidant function were compared between the two groups before and aftertreatment (after treatment 30 d). Results: There was no significant difference in the levels ofhs-CRP, WBC, ICAM-1, VCAM-1, SOD and MDA between the two groups before and aftertreatment; After treatment, the levels of hs-CRP, WBC, ICAM-1, VCAM-1 and MDA in theobservation group were significantly lower than those in control group, all significantly lowerthan the levels in the same group before treatment, the difference was statistically significant.After treatment, the level of SOD in the observation group was (100.37±9.45) U/mL, whichwas significantly higher than that of the control group (85.04±9.49) U/mL, which wassignificantly higher than that before the treatment, the difference was statistically significant.Conclusion: Ginkgo biloba extract adjuvant treatment of cerebral infarction significantly withhigh homocysteine hyperlipidemia efficacy can effectively reduce the inflammatory response tostress, reduce the release of adhesion molecules, improve the antioxidant function of oxidation,which has an important clinical value.