Effect of rehabilitation training combined with hyperbaric oxygen therapy on the nerve cytokine secretion and oxidative stress in rehabilitation period of patients with cerebral infarction

摘要

Objective: To discuss the influence of rehabilitation training combined with hyperbaricoxygen therapy on the nerve cytokine secretion and oxidative stress in rehabilitation periodof patients with cerebral infarction. Methods: A total of 110 patients with cerebral infarctionwho received rehabilitation therapy in the hospital between January 2015 and May 2017were divided into routine group (n=55) and hyperbaric oxygen group (n=55) according torandom number table. Routine group received regular rehabilitation training, and hyperbaricoxygen group underwent rehabilitation training combined with hyperbaric oxygen therapy.The differences in the serum contents of nerve factors, neurotransmitters and oxidative stressindexes were compared between the two groups at immediately after admission (T0) and after14 d of treatment (T1). Results: At T0, there was no statistically significant difference in theserum contents of nerve factors, neurotransmitters and oxidative stress indexes between the twogroups. At T1, serum nerve factors MBP and NSE contents of hyperbaric oxygen group werelower than those of routine group while NGF content was higher than that of routine group;serum neurotransmitter Glu content was lower than that of routine group while GABA contentwas higher than that of routine group; serum oxidative stress indexes ROS and LHP contentswere lower than those of routine group while CAT and SOD contents were higher than those ofroutine group. Conclusion: Rehabilitation training combined with hyperbaric oxygen therapycan effectively optimize the nerve function and inhibit the systemic oxidative stress response inrehabilitation period of patients with cerebral infarction.