Correlation of three grades with carotid atherosclerotic plaque by the ultrasound in middle-aged patients with hypertension

摘要

Objective: To explore the correlation of different hypertension grades with carotidatherosclerotic plaque in middle-aged patients with hypertension. Methods: A total of300 patients with primary hypertension who were admitted in the Cardiology Departmentand Neurology Department of our hospital from January, 2015 to September, 2016 wereincluded in the study and divided into 3 groups with 100 cases in each group according tothe hypertension grade criteria. Moreover, 100 normal individuals who came for physicalexaminations were served as the control group. TCD was used to detect MCA, ACA, PCA,VA1, and BA. CDFI was used to detect CCA, ICA, ECA, and VA2. EDV, PSV, PI, and RIwere detected, respectively. The nitrate reductase colorimetric method was used to detectNO, MDA, and SOD. Results: PSV and EDV in the internal carotid artery system in patientswith hypertension were significantly reduced (P0.05), while PI and RI were significantlyincreased (P0.05); moreover, with the increasing of hypertension grading, PSV and EDVwere gradually reduced, while PI and RI were increased. PSV and EDV in the vertebral arterysystem in patients with hypertension were significantly reduced (P0.05), while PI and RIwere significantly increased (P0.05); moreover, with the increasing of hypertension grading,PSV and EDV were gradually reduced, while PI and RI were increased. SOD and NO inpatients with hypertension were significantly lower than those in the control group (P0.05),while MDA was significantly higher than that in the control group (P0.05); moreover, withthe increasing of hypertension grading, SOD and NO were gradually reduced, while MDA wasgradually increased. Conclusions: TCD in combined with CDFI can make a comprehensiveevaluation of hemodynamic indicators of intracranial and extracranial vessels in patients withhypertension, and is of great significance in the early detection of intracranial and extracranialarteriosclerosis.