Effects of methotrexate combined with hydroxychloroquine sulfate and prednisone acetate on inflammatory response, immune function and liver and renal function in patients with systemic lupus erythematosus

摘要

Objective: To investigate the effects of methotrexate and hydroxychloroquine sulfate andprednisone on inflammatory response, immune function, liver and renal function in patientswith systemic lupus erythematosus (SLE). Methods: A total of 80 cases of SLE patientsaccording to the random data table were divided into the control group (n=40) and observationgroup (n=40), the control group were treated with hydroxychloroquine sulfate and prednisonetreatment, on the basis of treatment of the control group, patients in the observation group inthe control group were treated with methotrexate, the levels of inflammatory factors, immunefunction, liver and kidney function indexes in the two groups between the before treatmentand after treatment were compared. Results: Comparison of the levels before treatment, thedifference of the CRP, WBC, ESR, IgA, IgG, complement C3, complement C4, ALT, AST,SCr and BUN levels were not statistically significant. After treatment, the levels of CRP, ESR,IgA, IgG, ALT, AST, SCr and BUN in the observation group were significantly lower thanthose in the control group, and the difference was statistically significant. The levels of WBCand complement C4 in the observation group [(5.18±1.08)伊109 /L, (0.22±0.05) g/L] weresignificantly higher than those in the control group [(4.51±0.52)伊109 /L, (0.18±0.03) g/L],and there was no significant difference in the level of complement C3 between the two groupsafter treatment. Conclusion: Methotrexate combined with hydroxychloroquine sulfate andprednisone for the treatment of SLE can effectively reduce inflammation, improve immunefunction, has little effect on kidney function, high safety, which has an important clinical value.