Effect of adjuvant ozone autohemotherapy combined with naloxone therapy on respiratory function and neurological function in COPD patients with pulmonary encephalopathy

摘要

Objective: To study the effect of adjuvant ozone autohemotherapy combined with naloxonetherapy on respiratory function and neurological function in COPD patients with pulmonaryencephalopathy. Methods: A total of 30 COPD patients with pulmonary encephalopathy whowere treated in our hospital between May 2013 and January 2016 were collected and dividedinto the control group and observation group (n=15) according to the random number table.Control group of patients received conventional treatment + naloxone therapy, observationgroup of patients received conventional treatment + ozone autohemotherapy combined withnaloxone therapy, and the therapies lasted for 10 d. Differences in the levels of arterial bloodgas indexes, peripheral blood nerve injury indexes and cerebrospinal fluid nerve autophagyindexes were compared between two groups of patients before and after treatment. Results:Before treatment, differences in the levels of arterial blood gas indexes, peripheral bloodnerve injury indexes and cerebrospinal fluid nerve autophagy indexes were not statisticallysignificant between two groups of patients. After treatment, the arterial blood gas pH value andPaO2 level of observation group were higher than those of control group while PaCO2 level waslower than that of control group; peripheral blood nerve injury indexes S100β, NSE and MBPcontents were lower than those of control group; cerebrospinal fluid neural apoptosis indexesβ-GBA and Atg7 contents were lower than those of control group. Conclusion: Adjuvantozone autohemotherapy combined with naloxone therapy can optimize the respiratory functionand reduce the nerve injury in COPD patients with pulmonary encephalopathy.