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首页> 外文期刊>Journal of Hainan Medical University >Effects of Yinzhihuang oral liquid and albumin on bilirubin, inflammatory factors, immune indexes and related factors in neonatal pathologic jaundice
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Effects of Yinzhihuang oral liquid and albumin on bilirubin, inflammatory factors, immune indexes and related factors in neonatal pathologic jaundice

机译：银止黄口服液和白蛋白对新生儿病理性黄疸胆红素，炎性因子，免疫指标及相关因子的影响

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Objective: To explore the effects of Yinzhihuang oral liquid and albumin on bilirubin,inflammatory factors, immune indexes and related factors in neonatal pathologic jaundice.Methods: A total of 134 neonates with pathologic jaundice admitted to our hospital from May2017 to April 2018 were randomly selected as the control group (n=67) and the observationgroup (n=67), the control group was treated with albumin, the observation group was treatedwith Yinzhihuang Oral Liquid on the basis of the control group. The bilirubin, inflammatoryfactors, immune indicators, alpha-fetoprotein (AFP) and transferrin (TRF) were compared andanalyzed before and after treatment. Results: After treatment, the levels of TBIL, DBIL andIBIL in both groups were significantly lower than those before treatment (P0.05), and thelevels of TBIL, DBIL and IBIL [(118.60±10.85) μmol/L, (6.95±1.52) μmol/L, (115.30±14.20)μmol/L] in observation group were significantly lower than those in control group; the levelsof CRP and IL-6 in both groups were significantly lower than those before treatment (P0.05),and the levels of CRP and IL-6 [(8.26±2.07) mg/L, (12.69±2.15) pg/mL] in observation groupwere significantly lower than those in control group (P0.05); the levels of CD4+, CD4+/CD8+ in both groups were significantly higher than those before treatment (P0.05), whilethe levels of CD8+ was significantly lower than that before treatment, the levels of CD4+,CD4+/CD8+ [(47.08±5.70)%, (2.08±0.41)] in observation group were significantly higherthan those in control group (P0.05), and the level of CD8+ [(22.90±2.05)%] was significantlylower than that in control group (P0.05); the levels of AFP in significantly higher than beforetreatment (P0.05), and the levels of AFP [(12.69±3.04)mg/L] in observation group weresignificantly lower than those in control group (P0.05), the levels of TRF [(2.02±0.35) g/L]were significantly higher than those in control group (P0.05). Conclusions: The combinationof Yinzhihuang oral liquid and albumin can effectively reduce the bilirubin level in neonataljaundice, inhibit its inflammatory reaction, enhance the cellular immune function and improvethe expression of AFP and TRF, which is of clinical significance.
机译：目的：探讨银制黄口服液和白蛋白对新生儿病理性黄疸的胆红素，炎症因子，免疫指标及相关因子的影响。方法：2017年5月至2018年4月我院收治的134例病理性黄疸新生儿。作为对照组（n = 67）和观察组（n = 67），对照组给予白蛋白治疗，观察组在对照组的基础上给予银芝黄口服液治疗。比较治疗前后的胆红素，炎性因子，免疫指标，甲胎蛋白（AFP）和转铁蛋白（TRF）。结果：两组治疗后TBIL，DBIL和IBIL水平明显低于治疗前（P <0.05），TBIL，DBIL和IBIL水平[（118.60±10.85）μmol/ L，（6.95±1.52）。 ）μmol/ L，观察组（（115.30±14.20）μmol/ L]明显低于对照组。两组的CRP和IL-6水平均显着低于治疗前（P <0.05），CRP和IL-6水平[（8.26±2.07）mg / L，（12.69±2.15）pg / mL观察组中的]显着低于对照组（P <0.05）;两组的CD4 +，CD4 + / CD8 +水平明显高于治疗前（P <0.05），而CD8 +的水平显着低于治疗前，CD4 +，CD4 + / CD8 +的水平[（47.08±5.70）观察组％（2.08±0.41）]明显高于对照组（P <0.05），CD8 + [（22.90±2.05）％]水平显着低于对照组（P <0.05）。 AFP水平明显高于治疗前（P <0.05），观察组AFP水平[（12.69±3.04）mg / L]显着低于对照组（P <0.05），TRF水平[（2.02±0.35）g / L]明显高于对照组（P <0.05）。结论：银制黄口服液与白蛋白联用可有效降低新生儿黄疸中胆红素水平，抑制其炎症反应，增强细胞免疫功能，改善AFP和TRF的表达，具有临床意义。

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