Effect of adjuvant Naoxintong capsule therapy on nerve function and inflammatory stress response in patients in convalescence of cerebral infarction 82 Hong-Ping Wu

摘要

Objective: To explore the effect of adjuvant Naoxintong capsule therapy on nerve function and inflammatory stress response in patients in convalescence of cerebral infarction. Methods: 91 patients with cerebral infarction who were treated in our hospital between September 2015 and October 2017 were selected as the research subjects, and the medication during convalescence was reviewed and used to divide all patients into the control group (n=50) who received conventional western medicine treatment and the Naoxintong capsule group (n=41) who received western medicine combined with Naoxintong capsule treatment. The differences in serum levels of nerve function indexes, inflammatory mediators and oxidative stress indexes were compared between the two groups before convalescence medication (T1) and after 1 month of convalescence treatment (T2). Results: At T1, serum levels of nerve function indexes, inflammatory mediators and oxidative stress indexes were not significantly different between the two groups. At T2, serum nerve function indexes Copeptin and α-HBDH levels of Naoxintong capsule group were lower than those of control group whereas BDNF and IGF-1 levels were higher than those of control group; serum inflammatory mediators hs-CRP, YKL-40, IL-6 and IL-18 levels were lower than those of control group; serum oxidative stress index SOD level was higher than that of control group whereas 8-OHdG and MDA levels were lower than those of control group. Conclusion: Adjuvant Naoxintong capsule therapy can be further optimize the nerve function and relieve the inflammatory stress response in patients in convalescence of cerebral infarction.