Effect of Xuebijing, thymopentin combined with symptomatic treatment on inflammatory response process in elderly patients with severe pneumonia

摘要

Objective: To study the effect of Xuebijing, thymopentin combined with symptomatictreatment on inflammatory response process in elderly patients with severe pneumonia.Methods: A total of 60 elderly patients with severe pneumonia who were treated in thehospital between August 2014 and July 2016 were collected and divided into control groupand observation group according to the random number table, 30 cases in each group.Control group received clinical symptomatic treatment, and observation group receivedXuebijing, thymopentin combined with symptomatic treatment. The differences in serum proinflammatoryfactors, anti-inflammatory factors as well as liver and kidney function indexeswere compared between the two groups before and after treatment. Results: Before treatment,differences in serum levels of pro-inflammatory factors, anti-inflammatory factors as well asliver and kidney function indexes were not statistically significant between the two groups.After treatment, serum IL-1β, IL-6, IL-8, IL-4, IL-13, TB, ALT, AKP, Scr and CysC levels ofboth groups of patients were lower than those before treatment, and serum IL-1β, IL-6, IL-8,IL-4, IL-13, TB, ALT, AKP, Scr and CysC levels of observation group were lower than thoseof control group. Conclusion: Xuebijing, thymopentin combined with symptomatic treatmentcan effectively inhibit the degree of systemic inflammatory response and reduce the liver andkidney function injury in elderly patients with severe pneumonia.