Effect of clopidogrel and atorvastatin on hemorheology, inflammatory reaction and blood coagulation in patients with cerebral infarction

摘要

Objective: To observe the effect of clopidogrel combined with atorvastatin on hemorrheology, inflammation and coagulation in patients with cerebral infarction. Method: A total of 100 patients with cerebral infarction treated in our hospital from October 2015 to September 2017 were selected and divided into clopidogrel group and combination group according to random number table, each with 50 cases. The clopidogrel group received clopidogrel treatment, and the ombination group received atorvastatin treatment on the basis of clopidogrel group. The changes of hemorheology, inflammatory factors and coagulation were compared between the two groups. Results: There was no significant difference in the levels of hemorheology, inflammatory cytokines and coagulation function between the two groups before treatment. After treatment, the levels of HBV, LBV, PV, EAI and HTC decreased in both groups, and the five indexes in the combination group were significantly lower than those before treatment; while only HBV, PV, EAI and HTC in the clopidogrel group were significantly lower than those before treatment. After treatment, the levels of HBV and PV in the combination group were significantly lower than those in the clopidogrel group. After treatment, the levels of hs- CRP, TNF-α, MMP-9 in the two groups were significantly lower than those before treatment, and the levels of hs-CRP (14.94±6.21) mg/L, TNF-α (0.91±0.54) μg/L, and MMP-9 (1.93±0.29) μg/L in the combination group were significantly lower than those of clopidogrel group. After treatment, the levels of APTT and PT in the two groups had no significant changes, while the levels of Fib and DD were significantly lower than those before treatment. After treatment, the levels of APTT and PT in the combination group were higher than those in the clopidogrel group, but the difference was not significant. Fib level (3.02±1.06) g/L, DD level (0.27±0.08) mg/L of the combination group was significantly lower than those in the clopidogrel group. Conclusions: Clopidogrel combined with atorvastatin treatment of cerebral infarction can improve the patient's hemorheology level, and significantly reduce the body's inflammatory response, which plays a certain role in promoting the coagulation function. Thus it is worthy of clinical promotion.