Effect of helicobacter pylori L-form infection on proliferation, apoptosis and invasion molecule expression in gastric cancer tissue

摘要

Objective: To study the effect of Helicobacter pylori L-form infection on proliferation,apoptosis and invasion molecule expression in gastric cancer tissue. Methods: The gastriccancer tissues surgically removed in our hospital between May 2013 and October 2016were collected and divided into Hp negative, Hp-L negative and Hp-L positive accordingto the condition of helicobacter pylori infection. The proliferation, apoptosis and invasiongene expression were detected. Results: LOXL2, PCNA, CyclinD1, Rab1A, Bcl-2, Snail,N-cadherin, UHRF1 and AnnexinII mRNA expression in Hp-L-positive gastric cancer tissueswere significantly higher than those in Hp-L-negative and Hp-negative gastric cancer tissueswhile ING5, PTPN13, Beclin1 and Mst1 mRNA expression were significantly lower thanthose in Hp-L-negative and Hp-negative gastric cancer tissues; LOXL2, PCNA, CyclinD1,Rab1A, Bcl-2, ING5, PTPN13, Beclin1, Mst1, Snail, N-cadherin, UHRF1 and AnnexinIImRNA expression in Hp-L-negative gastric cancer tissues were not different from those in Hpnegativegastric cancer tissues. Conclusion: Helicobacter pylori L-form infection can influencethe proliferation, apoptosis and invasion gene expression to promote cell proliferation andinvasion, and inhibit cell apoptosis.