Effect of lipid-lowering anticoagulant therapy combined with compound Danshen dropping pill on the endothelial function and serum biochemical indexes in patients with hypertension and carotid atherosclerosis

摘要

Objective: To study the effect of lipid-lowering anticoagulant therapy combined withcompound Danshen dropping pill on the endothelial function and serum biochemicalindexes in patients with hypertension and carotid atherosclerosis. Methods: 98 patients withhypertension and carotid atherosclerosis treated in our hospital between June 2014 and July2016 were selected as the research subjects and randomly divided into the research groupwho received lipid-lowering anticoagulant therapy combined with compound Danshen andthe control group who received conventional lipid-lowering anticoagulant therapy. After 4weeks of treatment, endothelial injury indexes and lipid metabolism indexes in serum weredetermined. Results: After 4 weeks of treatment, serum endothelin-1 (ET-1), thromboxaneB2 (TXB2), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), oxidized lowdensity lipoprotein (ox-LDL), lipoprotein (a) [Lp(a)], leptin, resistin and chemerin levels ofresearch group were significantly lower than those of control group (P0.05) while nitric oxide(NO), 6-Keto-PGF1α, high-density lipoprotein cholesterol (HDL-C), adiponectin and visfatinlevels were significantly higher than those of control group (P0.05). Conclusion: Lipidloweringanticoagulant therapy combined with compound Danshen dropping pill can improvethe endothelial function and lipid metabolism in patients with hypertension and carotidatherosclerosis.