Synthesis and antidiabetic activity of some new chromonyl-2,4-thiazolidinediones

摘要

A series of chromonyl-2,4-thiazolidinediones/imidazolidinediones/2-thioxo-imidazolidine-4-ones ( IIIa–i , IVa–i ) was prepared by Knoevenagel reaction of 2,4-thiazolidinedione/2,4-imidazolidinedione/2-thioxo-imidazolidine-4-one ( IIa–c ) with 2/3-formyl chromone ( Ia–b ) and then alkylation with methyl/ethyl iodide. The prepared compounds were tested for their insulinotropic activities in INS-1 cells. Compounds ıV b and ıV c (at lower concentration, 1 μg/mL) were able to increase insulin release in the presence of 5.6 mmol/L glucose.” should be written as “Compounds IVb and IVc (at lower concentration, 1 µg/mL) and also IIId and IIIg (at higher concentration) were able to increase insulin release in the presence of 5.6 mmol/L glucose. Compounds ıV b and ıV c (at lower concentration, 1 μg/mL) were able to increase insulin release in the presence of 5.6 mmol/L glucose.