Evaluation of the proliferating activities of normal and carcinomatous prostatic tissues with Ki-67

摘要

In this study proliferation activities of normal prostate tissue, benign prostate hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN) and prostate cancer samples were evaluated immunohistochemically by using the monoclonal anti-Ki-67 antibody. Ki-67 is a nuclear non-histone protein expressed throughout the cell cycle. The proliferation rate was found to be 0.3-0.8 % in normal prostate glandular epithelium, 0.5-2.2 % in BPH, 1.6-3.7 % in high grade PIN and 5-30 % in prostate cancer cases. BPH showed a slightly higher, whereas PIN and prostate cancer showed significantly higher proliferation activity compared to normal prostate tissue. The Ki-67 proliferation index was found to correlate well with the Gleason classification in the cancer group. It is concluded that the Ki-67 proliferation index can be used a valuable diagnostic marker in PIN and tumor tissue.