Pentoxifylline for Diabetic Nephropathy- Current Status

摘要

Diabetic nephropathy, or diabetic kidney disease (DKD), is the most serious complication of diabetes mellitus (DM). Despite recent advances in therapy, DKD still often progresses to end-stage renal disease (ESRD). The current standard therapy of diabetic nephropathy involves intensive treatment of hyperglycemia and strict blood pressure control, mainly via blockade of the renin- angiotensin system (RAS). However, potential risk of hyperkalemia and on other hand antiproteinuric effects of RAS combination therapy do not seem to enhance the prevention of renal disease progression to complete extent. (1)