首页> 外文期刊>Dose-response >Effect of Health-Promoting Agents on Exclusion-Zone Size
【24h】

Effect of Health-Promoting Agents on Exclusion-Zone Size

机译:健康促进剂对禁区大小的影响

获取原文
           

摘要

It is now well-confirmed that hydrophilic surfaces including those within the cell generate structural changes in water. This interfacial water is ordered and acquires features different from the bulk. Amongst those features is the exclusion of colloidal and molecular solutes from extensive regions next to the hydrophilic surface, thereby earning it the label of “exclusion zone” (EZ) water. The transition of ordered EZ water to bulk serves as an important trigger of many cellular physiological functions, and in turn cellular health. We tested physiological doses of half a dozen agents generally identified to restore or build health on the extent to which they build EZs. All agents known to enhance biological function resulted in EZ expansion. On the other hand, the weed killer, glyphosate, considerably diminished EZ size. While the expansion effect of the health-promoting agents was observed over a wide range of concentrations, excessive doses ultimately reduced EZ size. We hypothesize that EZ buildup may be a mechanistic feature underlying many health-promoting agents, while agents that impair health may act by diminishing the amount of EZ water.
机译:现在已经充分证实,包括细胞内的亲水性表面会在水中产生结构变化。该界面水是有序的,并具有与体积不同的特征。这些特征包括从亲水表面附近的广大区域排除胶体和分子溶质,从而使其成为“排除区”(EZ)水的标签。有序的EZ水向大量过渡的过程是许多细胞生理功能以及细胞健康的重要触发因素。我们测试了生理剂量的六种药物,这些药物通常被确定可在其建立EZ的程度上恢复或增强健康。所有已知可增强生物学功能的物质均导致EZ扩展。另一方面,除草剂草甘膦大大减小了EZ的大小。虽然可以在很宽的浓度范围内观察到健康促进剂的扩张作用,但过量服用最终会缩小EZ的大小。我们假设EZ积累可能是许多促进健康的因素的机制特征,而损害健康的因素可能通过减少EZ水的量起作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号