Toxic nephropathy due to bromobenzene intoxication and the protective role of alternative medicines

摘要

Bromobenzene is an environmental toxin. Exposure to bromobenzene causes injury to hepatic and extra-hepatic tissues. The secondary metabolites of bromobenzene are toxic to kidneys. Bromobenzene is capable of causing ATP depletion, mitochondrial dysfunction, local inflammation, lipid peroxidation and subsequent loss of cellular function and integrity. This review provides insights into the mechanisms involved in bromobenzene intoxication and the effectiveness of several alternative medicines studied so far against bromobenzene-induced nephrotoxicity.