Improved process for the preparation A Long-acting ?22-adrenergic agonist (LABA) Salmeterol and identification, characterization and control of its potential process impurity

摘要

An improved and commercial viable process for the active pharmaceutical ingredient of new Long-acting β2- adrenergic agonist (LABA) Salmeterol has been developed. This improved process includes the isolation of Salmeterol 1 and identification, controlling and synthesis of its potential Diether impurity 2.