Data on chromosome changes in human neoplasms as detected with chromosome banding techniques have been compiled from the literature. Such data were available from a total of 287 cases representing 10 different groups of neoplastic conditions. Aberrations present in at least 20% of the cases within each tumor type were recorded, and it was found that only a few of the human chromosome types were engaged regularly in aberrations, viz. Nos. 7, 8, 9, 14, 17, 20, 21 and 22. Concordant results have been obtained in experimental tumors and it was hypothesized that the preferential involvement of a restricted number of chromosomes might indicate that these chromosomes carry genic sites of particular importance in malignant transformation.
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