THE HEPATITIS B VACCINE AND CELIAC DISEASE: MORE LIGHTS THAN SHADOWS?

摘要

Dear Editor: Actually, in literature, it is known that HLA-DQ2 haplotype is over-represented in celiac population and since both HBsAg protein fragments and gliadin peptides bind to HLA-DQ2 molecules; their competition may favors a defective antibody response against the recombinant HBsAg vaccine in active celiac disease. On the other hand, some studies demonstrate that in celiac individuals, the gluten intake at the time of vaccination influences the vaccine-induced immune response.