INFANTILE HEPATIC HEMANGIOENDOTHELIOMA IN COMPARISON WITH HEPATOBLASTOMA IN CHILDREN: CLINICAL AND ULTRASOUND FEATURES

摘要

Background: Infantile hepatic hemangioendothelioma (IHH) and hepatoblastoma (HBL) are respectively the most common benign and malignant liver tumors in children.Objective: To study the clinical manifestations and the ultrasound features of the pediatric patients for distinguishing IHH from HBL.Patients and Methods: Between 2002 and 2012, thirteen children with IHH and 38 children with HBL under the age of 10 years were included. We retrospectively reviewed the clinical and the ultrasound features of the two groups, especially including parameters as follows: age at diagnosis, gender, alpha-fetoprotein (AFP) elevation, venous involvement and Doppler ultrasound.Results: Compared with HBL group, the age of IHH group was much younger (5.8 months vs. 35.1 months, P = 0.000), the AFP elevation was less likely to be detected in IHH group (23.1% vs. 89.5%, P = 0.000). Although the color flow were the same commonly observed (61.5% vs. 52.6%, P>0.05), the spectral Doppler showed IHH was less likely to appear as arterial flow with resistance index (RI) > 0.7 (12.5% vs. 75.0%, PConclusions: The clinical features are effective indicators for distinguishing IHH from HBL, and the spectral Doppler may be a useful adjunct parameter for differential diagnosis.