Effect of Caffeic Acid Phenethyl Ester on Plasma Lipid Peroxidation, Antioxidant Status and Nitric Oxide Levels in Incisional Wound Model

摘要

Background and Design: Wound healing is a complex pathophysiologic process involving interplay of several cellular and biochemical processes. Several natural products have been shown to accelerate the healing process in studies. In this study we aimed to determine the efficacy of caffeic acid phenethyl ester (CAPE), which is an extract of honeybee propolis on wound healing in rats. MATERIALS-METHODS: Fourty male Wistar albino rats were divided into two groups as treatment (n=20) and control (n=20) group. A linear full thickness incision was performed on the back of each rat and sutured. After incision, during the study period CAPE was administered to the treatment group and saline was administered to the control group every day. Bloods of 5 animals from each group were collected on the experiment days of 1st, 3rd, 7th and 14th for biochemical analysis. RESULTS: A significant increase in glutathione and nitric oxide levels and a significant decrease in malondialdehyde levels and superoxide dismutase activities in CAPE group were detected when compared to the control group. CONCLUSION: In the study it determined that CAPE showed an antioxidant effect on wound healing and suppressed lipid peroxidation. In conclusion, because of these properties, CAPE may be useful in wound healing.