Does cytomegalovirus have a role in the etiology of mycosis fungoides?

摘要

Background and Design: It is controversial whether cytomegalovirus (CMV), an immunostimulator agent, plays a role in the etiopathogenesis of mycosis fungoides (MF). To investigate a possible linkage between CMV and MF, we designed a prospective clinical study. MATERIAL-METHOD: Patients with biopsy proven MF (n=29) and age/sex matched healthy control subjects (n=29) were included in the study. Sera of both groups were quantitatively investigated with micro-ELISA for the presence of anti- CMV immunoglobuline-G (IgG). RESULTS: All patients with MF had abnormally elevated levels of anti-CMV IgG in their sera, whereas 25 (86%) patients in control group showed higher levels of anti- CMV IgG than normal (p>0.05). The antibody levels measured in patients and healthy control subjects were 4.6 ± 1.2 ISR (range 2.6-6.6 ISR) and 4.1 ± 1.7 ISR (range 0.9-6.5 ISR), respectively (p>0.05). CONCLUSION: Levels of anti-CMV IgG in Turkish patients with MF are not significantly different than the levels of healthy control subjects.