Carotis Intima Media Thickness in Female Patiens with Subclinical Hypothyroidism - Orijinal Article

摘要

?zet Ama?: Klinik hipotiroidinin (KH) neden oldu?u dislipideminin, ateroskleroza ve kardiyovasküler hastal?klara sebep oldu?u bilinmektedir. Günümüzde yap?lan ?al??malar subklinik hipotiroidi (SKH)?nin de KH ile benzer kardiyovasküler risklere sahip oldu?unu g?stermektedir. Karotis intima media kal?nl??? (K?MK), aterosklerotik süre?te erken de?i?iklikler a??s?ndan ?nemli bir belirte? olup kardiyovasküler olay geli?iminin g?stergesidir. ?al??mam?zda, benzer ya? ve demografik ?zelliklere sahip KH ve SKH?li kad?n hastalarda K?MK?n? de?erlendirdik. Gere? ve Y?ntemler: ?al??maya Ocak ve Temmuz 2009 tarihleri aras?nda ?? hastal?klar? ve Endokrinoloji Poliklini?ine ayaktan müracaat eden, yap?lan tetkikler sonucu KH ve SKH saptanan, daha ?nce tedavi almam??, 30 KH?li, 51 SKH?li ve 38 sa?l?kl? kad?n dahil edildi. Hastalar?n vücut kitle indeksi (VK?), sistolik ve diyastolik kan bas?nc?, trigliserid (TG), total kolesterol (TC), LDL kolesterol (LDL-K), HDL kolesterol (HDL-K), vitamin B12, folat, homosistein, yüksek duyarl?kl? C-reaktif protein (Hs CRP) ve K?MK ?l?ümleri yap?ld?. Bulgular: Gruplar?n TG, TC, HDL-C, LDL-C, vitamin B-12, and folat düzeyleri aras?nda istatistiksel olarak fark yoktu (p>0,05). Gruplar aras?nda Hs CRP (p=0,011), homosistein (p0.05). On the other hand, SCH and CH groups differed statistically significantly from the control group for Hs CRP (p=0.011), homocysteine (p<0.001), and CIMT values. Additionally, age was found to be the most important factor for increase in CIMT when multiple linear regression analysis was performed. Conclusions: Lack of difference between CH patients and SCH patients in respect to Hs CRP, homocystein, and CIMT shows that inflammation and increase in CIMT starts during SCH period. Hence, we think that the increase in CIMT in SCH patients when TSH levels are higher than the normal range is a clinically important sign of early cardiovascular diseases. Turk Jem 2010; 14: 89-94