Basic Aspects of the Pharmacodynamics of Tolperisone, A Widely Applicable Centrally Acting Muscle Relaxant

摘要

Tolperisone (2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one hydro-chloride) was introduced in theclinical practice more than forty years ago and is still evaluated as a widely applicable compound in pathologically elevatedskeletal muscle tone (spasticity) and related pains of different origin. In the present review, basic pharmacodynamiceffects measured on whole animals, analyses of its actions on cell and tissue preparations and molecular mechanism of actionon sodium and calcium channels are summarized as recently significantly new data were reported.