Comparison of Adrenaline and Salbutamol nebulization in treatment of Children with Bronchiolitis.

摘要

Background: Bronchiolitis is an acute inflammation of bronchioles that canbe severe enough to require admission in intensive care unit. There are multiple modalitiesused for treatment of bronchiolitis. The objective of this study was to compare the response ofadrenaline and salbutamol nebulization in terms of clinical improvement and duration of hospitalstay. Study Design: Randomized controlled trial. Setting: Pediatrics Department of AvicennaMedical College and Hospital, Lahore. Period: March 2018 to October 2018. Methods: Total 66patients with 33 in each group between ages of 2-months to 3-years admitted with the diagnosisof bronchiolitis, were included in the study. Children in the group 1 were patients treated withsalbutamol nebulization 0.15 mg/kg with 3 ml normal saline every six hourly. Children in thegroup 2 received adrenaline nebulization 0.1 ml/kg of 1:1000 dilutions with 3 ml normal salineevery six hourly. Both the groups were given similar supportive management that includedoxygen therapy, intravenous fluids, and antipyretics. Data was collected in the form of age,gender, heart rate, respiratory rate, SpO2 and RDAI score at admission, 6hr, 24 hr and 48hrafter admission, duration of hospital stay and duration of oxygen therapy. Results: Out of 66patients, 38(57.6%) were male and 28(42%) were female. The mean with standard deviation ofage in months was 20.45 + 12.9 in salbutamol group and 16.7 + 12.3 in adrenaline group (pvalue = 0.23). Mean with standard deviation of weight of patients was 9.7+ 3.5 in salbutamolgroup and 8.9+3.3 in adrenaline group (p value =0.34). Regarding the duration of hospital staythe mean and standard deviation of hospital stay was 4.2+ 0.9 in salbutamol group and 3.9 +1 in adrenaline group with p value 0.016. Mean and standard deviation of duration of oxygentherapy was 1.05+ 0.7 in salbutamol group and 0.9+0.4 in adrenaline group with p value 0.42.There was no significant difference in the values of RDAI, heart rate, respiratory rate, SPO2 atadmission and subsequently after 6hrs, 24hrs, and 48hrs. Conclusion: We concluded thatthere was a significant reduction in duration of hospital stay in patients who received adrenalinenebulization then those nebulized with salbutamol. RDAI scores in the initial 48 hours in both thegroups were improved in successive readings, but there was no significant difference in RDAIscores between the two groups recorded at different time intervals.