Genetic Reconstruction of One Hereditary Nonpolyposis Colorectal Cancer History with Multiple Initiations of the Disease

Olga A. Vostrukhina; Tatyana A.Shtam; Alexey V. Gulyaev; Kazimir M.Pozharisski; Vladislav A. Lanzov

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Genetic Reconstruction of One Hereditary Nonpolyposis Colorectal Cancer History with Multiple Initiations of the Disease

机译：一种遗传性疾病的多发性遗传性非息肉性结直肠癌病史的遗传重建。

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The scheme of accumulation of genetic alterations in a long-term case of hereditary nonpolyposis colorectalcancer (HNPCC) was reconstructed by the retrospective analysis of postoperative tissue materials. This unique case resultedfrom a primary lesion in MLH1 gene and revealed two genetic pathways of carcinogenesis in tumors separated bylifetime and localization.

机译：通过对术后组织材料的回顾性分析，重建了长期遗传性非息肉性结直肠癌（HNPCC）病例中遗传改变的累积方案。这个独特的病例是由MLH1基因的原发灶引起的，并揭示了肿瘤的两条致癌遗传途径，按生命周期和局限性分开。

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《The Open Environmental & Biological Monitoring Journal》 |2008年第1期|共5页
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Olga A. Vostrukhina; Tatyana A.Shtam; Alexey V. Gulyaev; Kazimir M.Pozharisski; Vladislav A. Lanzov;
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中图分类环境科学基础理论;
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1. Clinical and genetic features of International Collaborative Group-hereditary nonpolyposis colorectal cancer families and suspected hereditary nonpolyposis colorectal cancer families [J] . YUAN Ying, YE Jun, ZHENG Shu Chinese Medical Journal . 2004,第5期

机译：国际合作组织遗传性非息肉病结直肠癌家族和疑似遗传性非息肉病结直肠癌家族的临床和遗传特征
2. Clinical and genetic features of International Collaborative Group-hereditary nonpolyposis colorectal cancer families and suspected hereditary nonpolyposis colorectal cancer families [J] . 袁瑛, 叶俊, 郑树中华医学杂志（英文版） . 2004,第005期

机译：国际合作组织遗传性非息肉性结直肠癌家族和疑似遗传性非息肉性结直肠癌家族的临床和遗传特征
3. Psychological Impact of Genetic Counseling for Hereditary Nonpolyposis Colorectal Cancer: The Role of Cancer History, Gender, Age, and Psychological Distress [J] . Monika I. Hasenbring, Nina Kreddig, Gabriele Deges, Genetic Testing . 2011,第4期

机译：遗传咨询对遗传性非息肉性结直肠癌的心理影响：癌症病史，性别，年龄和心理困扰的作用
4. Clinical Implications of Molecular Diagnosis in Hereditary Nonpolyposis Colorectal Cancer [C] . Gabriela Moslein International Meeting on Molecular Staging on Cancer . 2003

机译：遗传性非痘痘病变结直肠癌分子诊断的临床意义
5. Psychometric testing of a scale designed to monitor the psychosocial and behavioral impact of genetic testing for hereditary nonpolyposis colorectal cancer (HNPCC): A pilot study. [D] . LeDrew, Holly. 2009

机译：旨在监测遗传性非息肉病性结直肠癌（HNPCC）的基因测试对心理和行为影响的量表的心理测试：一项试点研究。
6. Microsatellite Stable Colorectal Cancers in Clinically Suspected Hereditary Nonpolyposis Colorectal Cancer Patients without Vertical Transmission of Disease Are Unlikely to Be Caused by Biallelic Germline Mutations in MYH [O] . Heike Görgens, Stefan Krüger, Eberhard Kuhlisch, 2006

机译：临床疑似遗传性非息肉病大肠癌患者中无垂直传播疾病的微卫星稳定大肠癌很可能是由MYH中的双等位基因生殖突变引起的
7. Microsatellite Stable Colorectal Cancers in Clinically Suspected Hereditary Nonpolyposis Colorectal Cancer Patients without Vertical Transmission of Disease Are Unlikely to Be Caused by Biallelic Germline Mutations in MYH [O] . Görgens, Heike, Krüger, Stefan, Kuhlisch, Eberhard, 2006

机译：临床可疑遗传性非息肉病大肠癌患者中无垂直传播疾病的微卫星稳定大肠癌很可能是由MYH中的双等位基因生殖突变引起的
8. Hereditary Nonpolyposis Colorectal Cancer: Diagnostic Strategies and Their Implications. Evidence Report/Technology Assessment Number 150. [R] . Bonis, P. A., Trikalinos, T. A., Chung, M., 2007

机译：遗传性非息肉病性结直肠癌：诊断策略及其意义。证据报告/技术评估编号150。

Genetic Reconstruction of One Hereditary Nonpolyposis Colorectal Cancer History with Multiple Initiations of the Disease

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