Genetic Predictors of Long-Term Response to Growth Hormone (GH) Therapy in Children With GH Deficiency and Turner Syndrome: The Influence of a SOCS2 Polymorphism

Adriana F. Braz; Everlayny F. Costalonga; Ericka B. Trarbach; Renata C. Scalco; Alexsandra C. Malaquias; Gil Guerra-Junior; Sonir R. R. Antonini; Berenice B. Mendonca; Ivo J. P. Arnhold; Alexander A. L. Jorge

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Genetic Predictors of Long-Term Response to Growth Hormone (GH) Therapy in Children With GH Deficiency and Turner Syndrome: The Influence of a SOCS2 Polymorphism

机译：生长激素缺乏症和特纳综合症儿童对生长激素（GH）治疗的长期反应的遗传预测因子：SOCS2多态性的影响。

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Background:There is great interindividual variability in the response to GH therapy. Ascertaining genetic factors can improve the accuracy of growth response predictions. Suppressor of cytokine signaling (SOCS)-2 is an intracellular negative regulator of GH receptor (GHR) signaling.

机译：背景：GH治疗的反应存在很大的个体差异。确定遗传因素可以提高生长反应预测的准确性。细胞因子信号传导（SOCS）-2的抑制因子是GH受体（GHR）信号传导的细胞内负调节剂。

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《The journal of clinical endocrinology and metabolism》 |2014年第9期|共6页
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Adriana F. Braz; Everlayny F. Costalonga; Ericka B. Trarbach; Renata C. Scalco; Alexsandra C. Malaquias; Gil Guerra-Junior; Sonir R. R. Antonini; Berenice B. Mendonca; Ivo J. P. Arnhold; Alexander A. L. Jorge;
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1. Genetic Predictors of Long-Term Response to Growth Hormone (GH) Therapy in Children With GH Deficiency and Turner Syndrome: The Influence of a SOCS2 Polymorphism [J] . Adriana F. Braz, Everlayny F. Costalonga, Ericka B. Trarbach, The journal of clinical endocrinology and metabolism . 2014,第9期

机译：生长激素缺乏症和特纳综合症儿童对生长激素（GH）治疗的长期反应的遗传预测因子：SOCS2多态性的影响。
2. Validating genetic markers of response to recombinant human growth hormone in children with growth hormone deficiency and Turner syndrome: the PREDICT validation study [J] . Adam Stevens, Philip Murray, Jerome Wojcik, European journal of endocrinology . 2016,第6期

机译：验证患有生长激素缺乏的儿童重组人生长激素的遗传标志物和特纳综合征：预测验证研究
3. Genetic Polymorphisms as Predictive Markers of Response to Growth Hormone Therapy in Children with Growth Hormone Deficiency [J] . Jung Anna Maria, Zenker Martin, Lissewski Christina, Klinische Paediatrie . 2017,第5期

机译：遗传多态性作为增长激素缺乏患儿生长激素治疗的预测标志
4. The growth hormone (GH) and insulin-like growth factor (IGF) system in girls and women with Turner syndrome [C] . Wieland Kiess, Jurgen Kratzsch, Roland Pfaeffl National Institute of Child Health and Human Development, National Institute of Health . 2006

机译：改变综合征的女孩和女性的生长激素（GH）和胰岛素样生长因子（IGF）系统
5. A Review of Genetic Polymorphisms in the Receptors for Gonadotropic and Sex Hormones in Polycystic Ovary Syndrome [D] . Rudolph, Sara 2017

机译：多囊卵巢综合征性激素和性激素受体的遗传多态性综述。
6. Validating genetic markers of response to recombinant human growth hormone in children with growth hormone deficiency and Turner syndrome: the PREDICT validation study [O] . Adam Stevens, Philip Murray, Jerome Wojcik, -1

机译：验证生长激素缺乏和特纳综合征患儿对重组人生长激素反应的遗传标记：PREDICT验证研究
7. Genetic Predictors of Long-Term Response to Growth Hormone (GH) Therapy in Children With GH Deficiency and Turner Syndrome: The Influence of a SOCS2 Polymorphism [O] . Adriana F. Braz, Everlayny F. Costalonga, Ericka B. Trarbach, 2014

机译：GH缺乏患儿生长激素（GH）治疗的长期反应遗传预测因子：SOCS2多态性的影响
8. Growth and Growth Hormone Therapy in Turner Syndrome (Groei en Groeihormoon Behandeling bij Patienten met het Syndroom van Turner) [R] . Rongen-Westerlaken, C. 1992

机译：特纳综合症的生长和生长激素治疗（Groei en Groeihormoon Behandeling bij patienten遇见het syndroom van Turner）

Genetic Predictors of Long-Term Response to Growth Hormone (GH) Therapy in Children With GH Deficiency and Turner Syndrome: The Influence of a SOCS2 Polymorphism

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